Infinity Pharmaceuticals Inc. (INFI) Company Profile
Infinity Pharmaceuticals, Inc. engages in the discovery and development of medicines for difficult-to-treat diseases. The company?s lead product candidates include saridegib (IPI-926), an oral molecule with the potential to treat a range of cancers by disrupting malignant activation of the Hedgehog pathway; and Retaspimycin HCl (IPI-504), a heat shock protein 90 (Hsp90) inhibitor. Its Saridegib is in a Phase II clinical trial for the treatment of metastatic or inoperable chondrosarcoma and a Phase II exploratory trial in patients with myelofibrosis. The company?s Retaspimycin HCl is in a Phase II trial in combination with docetaxel to treat patients with non-small cell lung cancer (NSCLC); and in a Phase Ib/II trial in combination with everolimus, known as Afinitor, in approximately 45 NSCLC patients with a KRAS mutation. Its pipeline also includes IPI-145, an inhibitor of the delta and gamma isoforms of phosphoinositide-3-kinase (PI3K) in Phase I development to treat in flammation and hematologic malignancies. Infinity Pharmaceuticals has a strategic alliance with Purdue Pharmaceutical Products L.P. and Mundipharma International Corporation Limited to develop and commercialize pharmaceutical products; and a development and license agreement with Millennium to discover, develop, and commercialize pharmaceutical products targeting the delta and/or gamma isoforms of PI3K, including IPI-145. Purdue Pharmaceutical Products is planning to conduct Phase II studies of IPI-940 in pain. The company is headquartered in Cambridge, Massachusetts.
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